IL-17 is necessary for host protection against acute-phase Trypanosoma cruzi infection.

@article{Miyazaki2010IL17IN,
  title={IL-17 is necessary for host protection against acute-phase Trypanosoma cruzi infection.},
  author={Yoshiyuki Miyazaki and Shinjiro Hamano and Seng Wang and Yohei Shimanoe and Yoichiro Iwakura and Hiroki Yoshida},
  journal={Journal of immunology},
  year={2010},
  volume={185 2},
  pages={1150-7}
}
IL-17A is a key cytokine that induces inflammatory responses through the organized production of inflammatory cytokines, such as IL-6, TNF-alpha, and GM-CSF, and induces neutrophil migration. The roles of IL-17A in infection of intracellular protozoan parasites have not been elucidated, although augmented immune responses by IL-17A are important for the resolution of some bacterial and fungal infections. Therefore, we experimentally infected IL-17A-deficient (IL-17A(-/-)) mice with Trypanosoma… CONTINUE READING