IL-17 family cytokines and the expanding diversity of effector T cell lineages.

@article{Weaver2007IL17FC,
  title={IL-17 family cytokines and the expanding diversity of effector T cell lineages.},
  author={Casey T. Weaver and Robin D. Hatton and Paul R. Mangan and Laurie E. Harrington},
  journal={Annual review of immunology},
  year={2007},
  volume={25},
  pages={
          821-52
        }
}
Since its conception two decades ago, the Th1-Th2 paradigm has provided a framework for understanding T cell biology and the interplay of innate and adaptive immunity. Naive T cells differentiate into effector T cells with enhanced functional potential for orchestrating pathogen clearance largely under the guidance of cytokines produced by cells of the innate immune system that have been activated by recognition of those pathogens. This secondary education of post-thymic T cells provides a… 

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