IL-17-committed Vγ4+ γδ T cell deficiency in a spontaneous Sox13 mutant CD45.1 congenic mouse substrain protects from dermatitis

@inproceedings{Gray2013IL17committedV,
  title={IL-17-committed Vγ4+ γδ T cell deficiency in a spontaneous Sox13 mutant CD45.1 congenic mouse substrain protects from dermatitis},
  author={Elizabeth E. Gray and Francisco Ram{\'i}rez-Valle and Ying Xu and Shuang Wu and Zhihao Wu and Klaus Erik Karjalainen and Jason G Cyster},
  booktitle={Nature Immunology},
  year={2013}
}
Interleukin 17 (IL-17)-committed γδ T cells (γδT17 cells) participate in many immune responses, but their developmental requirements and subset specific functions remain poorly understood. Here we report that a commonly used CD45.1+ congenic C57BL/6 mouse substrain is characterized by selective deficiency in Vγ4+ γδT17 cells. This trait was due to a spontaneous mutation in the gene encoding the transcription factor Sox13 that caused an intrinsic defect in development of those cells in the… CONTINUE READING

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