IL-17 activates the canonical NF-kappaB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16.

Abstract

We previously identified that autoreactive B cells from BXD2 mice can be targeted by IL-17, leading to upregulation of the expression of regulators of G-protein signaling (Rgs) genes that facilitated the development of spontaneous germinal centers. Little is known about the signaling pathway used by IL-17 to upregulate RGS. In the current study, we found… (More)
DOI: 10.4049/jimmunol.0903133

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@article{Xie2010IL17AT, title={IL-17 activates the canonical NF-kappaB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16.}, author={Shutao Xie and Jun Li and John C. H. Wang and Qi Wu and Pingar Yang and Hui-Chen Hsu and Lesley E. Smythies and John D. Mountz}, journal={Journal of immunology}, year={2010}, volume={184 5}, pages={2289-96} }