IL-17 Receptor Signaling in the Lung Epithelium Is Required for Mucosal Chemokine Gradients and Pulmonary Host Defense against K. pneumoniae.

@article{Chen2016IL17RS,
  title={IL-17 Receptor Signaling in the Lung Epithelium Is Required for Mucosal Chemokine Gradients and Pulmonary Host Defense against K. pneumoniae.},
  author={Kong Chen and Taylor Eddens and Giraldina J. Trevejo-Nu{\~n}ez and Emily E. Way and Waleed Elsegeiny and David M Ricks and Abhishek V. Garg and Carla J Erb and Meihua Bo and Ting Wang and Wei Chen and Janet Suzanne Lee and Sarah L Gaffen and Jay K Kolls},
  journal={Cell host & microbe},
  year={2016},
  volume={20 5},
  pages={
          596-605
        }
}
The cytokine IL-17, and signaling via its heterodimeric IL-17RA/IL-17RC receptor, is critical for host defense against extracellular bacterial and fungal pathogens. Polarized lung epithelial cells express IL-17RA and IL-17RC basolaterally. However, their contribution to IL-17-dependent pulmonary defenses in vivo remains to be determined. To address this, we generated mice with conditional deletion of Il17ra or Il17rc in Scgb1a1-expressing club cells, a major component of the murine bronchiolar… CONTINUE READING
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