IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential.

  title={IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential.},
  author={Shu Zhu and Youcun Qian},
  journal={Clinical science},
  volume={122 11},
IL-17 (interleukin-17), a hallmark cytokine of Th17 (T-helper 17) cells, plays critical roles in host defence against bacterial and fungal infections, as well as in the pathogenesis of autoimmune diseases. The present review focuses on current knowledge of the regulation, functional mechanisms and targeting strategies of IL-17 in the context of inflammatory autoimmune diseases. Evidence shows that IL-17 is highly up-regulated at sites of inflammatory tissues of autoimmune diseases and amplifies… 

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