IL-17: a new actor in IFN-driven systemic autoimmune diseases.

@article{Ambrosi2012IL17AN,
  title={IL-17: a new actor in IFN-driven systemic autoimmune diseases.},
  author={Aur{\'e}lie Ambrosi and Alexander Espinosa and Marie Wahren-Herlenius},
  journal={European journal of immunology},
  year={2012},
  volume={42 9},
  pages={2274-84}
}
Systemic autoimmune diseases such as systemic lupus erythematosus are type I IFN-driven diseases with exaggerated B-cell responses and autoantibody production. Th17 cells, a T-helper-cell subset with high inflammatory capacity, was initially discovered and characterized in the context of experimental autoimmune encephalomyelitis - an animal model of multiple sclerosis. There is now emerging evidence that Th17 cells, and more generally IL-17 and IL-17-producing cells, may play a role in the… CONTINUE READING