IL-17/IFN-γ interactions regulate intestinal inflammation in TNBS-induced acute colitis.

@article{Jin2012IL17IFNIR,
  title={IL-17/IFN-γ interactions regulate intestinal inflammation in TNBS-induced acute colitis.},
  author={Yu Jin and Yan Lin and Lian-jie Lin and Changqing Zheng},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={2012},
  volume={32 11},
  pages={548-56}
}
Colonic administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS) induced acute colitis in mice and elicited a Th1 immune response. Th17 cells are believed to play a major role in TNBS-induced colitis. The aim of this study is to investigate the roles of interleukin (IL)-17 and interferon (IFN)-γ in the pathogenesis of TNBS-induced acute colitis. We assessed the inflammation scores of TNBS-induced acute colitis in wild-type (WT), IL-17 knockout (KO), and IFN-γ KO mice and measured the levels… CONTINUE READING