IL-15.IL-15Rα complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cells.

@article{Tamzalit2014IL15IL15RCS,
  title={IL-15.IL-15Rα complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cells.},
  author={Fella Tamzalit and Isabelle Barbieux and Ariane Plet and Julie Heim and Steven N{\'e}dellec and S{\'e}bastien Morisseau and Yannick Jacques and Erwan Mortier},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 23},
  pages={8565-70}
}
Interleukin (IL)-15 and its specific receptor chain, IL-15Rα, support the development of various effector cells, including NK and CD8 T cells via a mechanism called trans-presentation. Whereas the dynamic of trans-presentation has been shown to involve the recycling of IL-15Rα by presenting cells, the way responding cells integrate, or take advantage of this process has not been evaluated yet. To address this question, we set up a trans-presentation model using a membrane-bound IL-15.IL-15R… CONTINUE READING