IL-15 modulates the effect of retinoic acid, promoting inflammation rather than oral tolerance to dietary antigens.

@article{Arranz2011IL15MT,
  title={IL-15 modulates the effect of retinoic acid, promoting inflammation rather than oral tolerance to dietary antigens.},
  author={Eduardo Mart{\'i}n Arranz and Jos{\'e} Antonio Garrote},
  journal={Expert review of gastroenterology & hepatology},
  year={2011},
  volume={5 3},
  pages={315-7}
}
The physiological immune response in the intestine against dietary proteins and commensal flora is characterized by regulatory mechanisms (tolerance) that prevent harmful consequences. Intestinal dendritic cells (DCs) have a central role in the development of immunosuppressive regulatory T cells owing to their ability to produce TGF-β and retinoic acid (RA). However, the article under evaluation shows an unexpected effect of RA - that of promoting a proinflammatory phenotype in intestinal DCs… CONTINUE READING
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