IL-15 is decreased upon CsA and FK506 treatment of acute rejection following heart transplantation in mice

@inproceedings{Yu2015IL15ID,
  title={IL-15 is decreased upon CsA and FK506 treatment of acute rejection following heart transplantation in mice},
  author={Zhiyong Yu and Xiaoping Zhou and Songfeng Yu and Hai-Yang Xie and Shusen Zheng},
  booktitle={Molecular medicine reports},
  year={2015}
}
The aim of this study was to investigate the effect of cyclosporine A (CsA) and tacrolimus (FK506) on interleukin-15 (IL-15) production during acute rejection following heart transplantation in mice. Inbred male Balb/c (H‑2d) and C57BL/6 (H-2b) mice were used to establish a heterotopic intra-abdominal cardiac transplantation model. The mice were divided in four groups: syngeneic control, allogeneic acute rejection, allogeneic rejection treated with CsA, and allogeneic rejection treated with… CONTINUE READING