IL-15 is an essential mediator of peripheral NK-cell homeostasis.

@article{Ranson2003IL15IA,
  title={IL-15 is an essential mediator of peripheral NK-cell homeostasis.},
  author={Thomas Ranson and Christian A. J. Vosshenrich and Erwan Corcuff and Odile Richard and Werner M{\"u}ller and James P Di Santo},
  journal={Blood},
  year={2003},
  volume={101 12},
  pages={4887-93}
}
Several distinct classes of surface receptors can, on ligand binding, transmit signals that modulate the survival, proliferation, and apoptosis of peripheral B, T, and natural killer (NK) cells. At the population level, dynamic changes in lymphocyte cell numbers are strictly regulated to maintain a steady state, a process referred to as homeostasis. Although several studies have investigated the signals that regulate B- and T-cell homeostasis, little is known about the mechanisms that control… CONTINUE READING