IL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitro.

@article{Alves2003IL15IA,
  title={IL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitro.},
  author={Nuno L Alves and Berend Hooibrink and Fernando A. Arosa and Ren{\'e} AW van Lier},
  journal={Blood},
  year={2003},
  volume={102 7},
  pages={2541-6}
}
Recent studies in mice have shown that although interleukin 15 (IL-15) plays an important role in regulating homeostasis of memory CD8+ T cells, it has no apparent function in controlling homeostatic proliferation of naive T cells. We here assessed the influence of IL-15 on antigen-independent expansion and differentiation of human CD8+ T cells. Both naive and primed human T cells divided in response to IL-15. In this process, naive CD8+ T cells successively down-regulated CD45RA and CD28 but… CONTINUE READING