IL-15 drives neonatal T cells to acquire CD56 and become activated effector cells.

@article{Cookson2003IL15DN,
  title={IL-15 drives neonatal T cells to acquire CD56 and become activated effector cells.},
  author={Sharon Cookson and Denis J. Reen},
  journal={Blood},
  year={2003},
  volume={102 6},
  pages={2195-7}
}
Expression of one or more natural killer (NK) receptors on T cells may correlate with effector function. This study investigated the frequency of neonatal NK receptor-positive (NKR+) T cells and their expansionary properties with interleukin-2 (IL-2), IL-7, or IL-15. While cord blood contains significantly decreased frequencies of NKR+ T cells compared with adult blood, newborn CD56+CD3+ cells could be expanded 200-fold during culture with IL-15. By depleting CD56+ cells, we were able to… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Similar Papers

Loading similar papers…