IL-15 aggravates atherosclerotic lesion development in LDL receptor deficient mice.

Abstract

BACKGROUND Interleukin 15 (IL-15) is a pro-inflammatory cytokine involved in inflammatory diseases and IL-15 is expressed in atherosclerotic plaques. METHODS To establish the role of IL-15 in atherosclerosis we studied the effect of IL-15 on atherosclerosis associated cells in vitro and in vivo by neutralizing IL-15 using a DNA vaccination strategy… (More)
DOI: 10.1016/j.vaccine.2010.11.037

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