IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8+ T effector memory population in peripheral blood.

@article{Sneller2011IL15AB,
  title={IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8+ T effector memory population in peripheral blood.},
  author={Michael C Sneller and William C Kopp and Kory J. Engelke and Jason L. Yovandich and Stephen P. Creekmore and Thomas A. Waldmann and H. Clifford Lane},
  journal={Blood},
  year={2011},
  volume={118 26},
  pages={6845-8}
}
IL-15 promotes activation and maintenance of natural killer (NK) and CD8(+) T effector memory (T(EM)) cells, making it a potential immunotherapeutic agent for the treatment of cancer and immunodeficiency states. Here we report the immunologic effects of 3 different IL-15 dosing strategies in Rhesus macaques. IL-15 at a dose of 20 μg/kg/d administered by continuous intravenous infusion for 10 days resulted in a massive (100-fold) expansion of CD8(+) T(EM) cells in the peripheral blood. In… CONTINUE READING
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