IL-13Rα2-bearing, type II NKT cells reactive to sulfatide self-antigen populate the mucosa of ulcerative colitis.

@article{Fuss2014IL13R2bearingTI,
  title={IL-13Rα2-bearing, type II NKT cells reactive to sulfatide self-antigen populate the mucosa of ulcerative colitis.},
  author={Ivan Fuss and Bharat H. Joshi and Zhiqiong Yang and Heba A Degheidy and Stefan Fichtner-Feigl and Heitor Soares de Souza and F Rieder and Franco Scaldaferri and Anja Schirbel and Melania Scarpa and Gail A. West and Chuli Yi and LiLi Xu and Pamela Leland and Michael D. Yao and Peter J. Mannon and Raj K. Puri and Claudio Fiocchi and Warren Strober},
  journal={Gut},
  year={2014},
  volume={63 11},
  pages={1728-36}
}
OBJECTIVE Previous studies have shown that ulcerative colitis (UC) is associated with the presence of lamina propria non-invariant (Type II) NKT cells producing IL-13 and mediating epithelial cell cytotoxicity. Here we sought to define the antigen(s) stimulating the NKT cells and to quantitate these cells in the UC lamina propria. DESIGN Detection of Type II NKT cells in UC lamina propria mononuclear cells (LPMC) with lyso-sulfatide loaded tetramer and quantum dot-based flow cytometry and… CONTINUE READING