IL-13 signaling via IL-13R alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis.

@article{FichtnerFeigl2008IL13SV,
  title={IL-13 signaling via IL-13R alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis.},
  author={Stefan Fichtner-Feigl and Cheryl A. Young and Atsushi Kitani and Edward Kenneth Geissler and Hans-Juergen Schlitt and Warren Strober},
  journal={Gastroenterology},
  year={2008},
  volume={135 6},
  pages={
          2003-13, 2013.e1-7
        }
}
BACKGROUND & AIMS Previous studies have shown that fibrosis developing in chronic experimental colitis is driven by interleukin (IL)-13 signaling via IL-13R alpha(2) and the production of transforming growth factor (TGF)-beta1. In the present study, we sought to determine the fibrogenic downstream events set in motion by such signaling. METHODS Experimental colitis with late-onset intestinal fibrosis was induced by weekly intrarectal administration of trinitrobenzene sulfonic acid (TNBS) to… CONTINUE READING

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