IL-13 receptors and signaling pathways: an evolving web.

  title={IL-13 receptors and signaling pathways: an evolving web.},
  author={Gurjit K. Khurana Hershey},
  journal={The Journal of allergy and clinical immunology},
  volume={111 4},
  pages={677-90; quiz 691}
IL-13 is an immunoregulatory cytokine secreted predominantly by activated T(H)2 cells. Over the past several years, it has become evident that IL-13 is a key mediator in the pathogenesis of allergic inflammation. IL-13 shares many functional properties with IL-4, stemming from the fact that they share a common receptor subunit, the alpha subunit of the IL-4 receptor (IL-4Ralpha). Characterization of IL-13-deficient mice, IL-4-deficient mice, and IL-4 receptor alpha-deficient (IL-4Ralpha… CONTINUE READING
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