IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension.

@article{Cho2013IL13R,
  title={IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension.},
  author={Won-Kyung Cho and Chang-Min Lee and Min-Jong Kang and Yan Huang and Frank J. Giordano and Patty J Lee and Terence K. Trow and Robert J Homer and William C Sessa and Jack A Elias and Chun Geun Lee},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2013},
  volume={304 2},
  pages={L112-24}
}
Although previous literature suggests that interleukin (IL)-13, a T-helper type 2 cell effector cytokine, might be involved in the pathogenesis of pulmonary hypertension (PH), direct proof is lacking. Furthermore, a potential mechanism underlying IL-13-induced PH has never been explored. This study's goal was to investigate the role and mechanism of IL-13 in the pathogenesis of PH. Lung-specific IL-13-overexpressing transgenic (Tg) mice were examined for hemodynamic changes and pulmonary… CONTINUE READING
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