IL-13 protects mice from lipopolysaccharide-induced lethal endotoxemia: correlation with down-modulation of TNF-alpha, IFN-gamma, and IL-12 production.

@article{Muchamuel1997IL13PM,
  title={IL-13 protects mice from lipopolysaccharide-induced lethal endotoxemia: correlation with down-modulation of TNF-alpha, IFN-gamma, and IL-12 production.},
  author={Tony Muchamuel and Satish Menon and Paul I. Pisacane and Maureen C. Howard and Debra A. Cockayne},
  journal={Journal of immunology},
  year={1997},
  volume={158 6},
  pages={2898-903}
}
IL-13 is a potent down-modulator of macrophage proinflammatory activity in vitro, similar in this context to the anti-inflammatory cytokines IL-4 and IL-10. Since IL-10 effectively confers protection to mice from LPS-induced lethal endotoxemia through inhibition of proinflammatory cytokine production, we investigated whether IL-13 may also be capable of… CONTINUE READING