IL-13 is necessary, not simply sufficient, for epicutaneously induced Th2 responses to soluble protein antigen.

@article{Herrick2003IL13IN,
  title={IL-13 is necessary, not simply sufficient, for epicutaneously induced Th2 responses to soluble protein antigen.},
  author={Christina A. Herrick and Lan Xu and Andrew N. J. McKenzie and Robert E. Tigelaar and Kim Bottomly},
  journal={Journal of immunology},
  year={2003},
  volume={170 5},
  pages={2488-95}
}
Th2 responses are clearly involved in the pathogenesis of atopic disease. Thus, understanding the factors responsible for Th2 sensitization at sites of allergen exposure, such as airway and skin, is crucial for directing therapeutic or preventive strategies. Contrary to other models of Th2 sensitization to proteins, we have reported that Th2 responses induced by epicutaneous exposure to OVA are IL-4 independent. Combined deficiency of both IL-4 and IL-13 signaling did prevent Th2 generation… CONTINUE READING
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