IL-13 induces airways hyperreactivity independently of the IL-4R alpha chain in the allergic lung.


The potent spasmogenic properties of IL-13 have identified this molecule as a potential regulator of airways hyperreactivity (AHR) in asthma. Although IL-13 is thought to primarily signal through the IL-13Ralpha1-IL-4Ralpha complex, the cellular and molecular components employed by this cytokine to induce AHR in the allergic lung have not been identified… (More)


  • Presentations referencing similar topics