IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling.

@article{Zhu2002IL13inducedCR,
  title={IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling.},
  author={Zhou Zhu and Bing Ma and Tao Zheng and Robert J Homer and Chun Geun Lee and Israel F. Charo and Paul James Noble and Jack A Elias},
  journal={Journal of immunology},
  year={2002},
  volume={168 6},
  pages={2953-62}
}
IL-13 stimulates inflammatory and remodeling responses and contributes to the pathogenesis of human airways disorders. To further understand the cellular and molecular events that mediate these responses, we characterized the effects of IL-13 on monocyte chemotactic proteins (MCPs) and compared the tissue effects of transgenic IL-13 in mice with wild-type (+/+) and null (-/-) CCR2 loci. Transgenic IL-13 was a potent stimulator of MCP-1, -2, -3, and -5. This stimulation was not specific for MCPs… CONTINUE READING