IL-13-induced airway mucus production is attenuated by MAPK13 inhibition.

@article{Alevy2012IL13inducedAM,
  title={IL-13-induced airway mucus production is attenuated by MAPK13 inhibition.},
  author={Yael G. Alevy and Anand C Patel and A M Gabirela Romero and Dhara Anand Patel and Jennifer A. Tucker and William T. Roswit and Chantel A Miller and Richard Frederick Heier and Derek E. Byers and Tom J Brett and Michael J Holtzman},
  journal={The Journal of clinical investigation},
  year={2012},
  volume={122 12},
  pages={
          4555-68
        }
}
Increased mucus production is a common cause of morbidity and mortality in inflammatory airway diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. However, the precise molecular mechanisms for pathogenic mucus production are largely undetermined. Accordingly, there are no specific and effective anti-mucus therapeutics. Here, we define a signaling pathway from chloride channel calcium-activated 1 (CLCA1) to MAPK13 that is responsible for IL-13-driven… CONTINUE READING
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