IL-13 effector functions.

@article{Wynn2003IL13EF,
  title={IL-13 effector functions.},
  author={Thomas A. Wynn},
  journal={Annual review of immunology},
  year={2003},
  volume={21},
  pages={
          425-56
        }
}
IL-13 was first recognized for its effects on B cells and monocytes, where it upregulated class II expression, promoted IgE class switching and inhibited inflammatory cytokine production. It was also thought to be functionally redundant with IL-4. However, studies conducted with knockout mice, neutralizing antibodies, and novel antagonists demonstrate that IL-13 possesses several unique effector functions that distinguish it from IL-4. Resistance to most gastrointestinal nematodes is mediated… CONTINUE READING
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