IL-12p40 is not required for islet allograft rejection

  title={IL-12p40 is not required for islet allograft rejection},
  author={En-guang Bi and Wei Shi and Jia Zou and Zhen-hua Hao and Zhen-hu Li and Duan Cai and Hua-qun Zhang and Bing Sun},
  journal={Acta Pharmacologica Sinica},
AbstractAim:To investigate whether IL-12p40 plays a crucial role in regulating islet allograft rejection in a streptozotocin (STZ)-induced diabetes mouse model.Methods:C57BL/6 and IL-12p40 gene knockout mice were selected as recipient mice, to which the diabetes was induced with a treatment of STZ (150–200 mg/kg) by a single ip injection. BALB/c mice were… CONTINUE READING