IL-12 suppresses the expression of ocular immunoinflammatory lesions by effects on angiogenesis.

@article{Lee2002IL12ST,
  title={IL-12 suppresses the expression of ocular immunoinflammatory lesions by effects on angiogenesis.},
  author={Sujin Lee and Mei Zheng and Shilpa Deshpande and Seong-kug Eo and Thomas A Hamilton and Barry T Rouse},
  journal={Journal of leukocyte biology},
  year={2002},
  volume={71 3},
  pages={469-76}
}
Topical application of plasmid DNA encoding IL-12 to the cornea of mice prior to ocular infection with Herpes simplex virus type 1 (HSV) results in diminished corneal immunoinflammatory lesions. Such herpetic stromal keratitis (HSK) reactions in humans represent an important cause of blindness. The effect of IL-12 pretreatment acted via inhibitory effects on corneal neovascularization rather than by inhibiting viral replication or the function of CD4(+) T cells that mediate HSK. The… CONTINUE READING
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