IL-12 selectively regulates STAT4 via phosphatidylinositol 3-kinase and Ras-independent signal transduction pathways.

@article{AthiM2000IL12SR,
  title={IL-12 selectively regulates STAT4 via phosphatidylinositol 3-kinase and Ras-independent signal transduction pathways.},
  author={V Athi{\'e}-M and Horst Flotow and Katherine L Hilyard and Doreen A Cantrell},
  journal={European journal of immunology},
  year={2000},
  volume={30 5},
  pages={1425-34}
}
IL-12 is an important immunomodulatory cytokine that induces tyrosine phosphorylation and activation of the signal transducer and activator of transcription (STAT)4. IL-12 induces sustained activation and nuclear translocation of STAT4 and this regulatory process is coupled to both tyrosine and serine phosphorylation of this molecule. IL-12-activated tyrosine kinases are the Janus kinases Jak2 and Tyk2 but little is known about IL-12 regulation of serine kinases. The object of the present study… CONTINUE READING