IL-12 responsiveness and expression of IL-12 receptor in human peripheral blood monocyte-derived dendritic cells.

@article{Nagayama2000IL12RA,
  title={IL-12 responsiveness and expression of IL-12 receptor in human peripheral blood monocyte-derived dendritic cells.},
  author={Hitomi Nagayama and Katsuaki Sato and Hiroshi Kawasaki and Makoto Enomoto and Chikao Morimoto and Kenji Tadokoro and Takeo Juji and Shigetaka Asano and Tsuneo A. Takahashi},
  journal={Journal of immunology},
  year={2000},
  volume={165 1},
  pages={59-66}
}
We analyzed the expression of IL-12Rbeta1 and IL-12Rbeta2 and the role of IL-12 in the activation of monocyte-derived dendritic cells (DCs) via IL-12Rbeta1-mediated signaling events. Flow cytometric analysis revealed that IL-12Rbeta1 was expressed in T cells, Con A blasts, and monocyte-derived DCs, but not in monocytes, while its transcript was detected in all of these cell types. Transcriptional expression of IL-12Rbeta2 was observed in T cells, Con A blasts, and monocyte-derived DCs, but not… CONTINUE READING
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