IL-12 is both required and sufficient for initiating T cell reactivity to a class I-restricted tumor peptide (P815AB) following transfer of P815AB-pulsed dendritic cells.

@article{Bianchi1996IL12IB,
  title={IL-12 is both required and sufficient for initiating T cell reactivity to a class I-restricted tumor peptide (P815AB) following transfer of P815AB-pulsed dendritic cells.},
  author={Roberta Bianchi and Ursula Grohmann and Maria Laura Belladonna and Silvia Silla and Francesca Fallarino and Emira Ayroldi and Maria Cristina Fioretti and Paolo Puccetti},
  journal={Journal of immunology},
  year={1996},
  volume={157 4},
  pages={1589-97}
}
Delayed-type hypersensitivity responses, mediated by CD8+ cells and detected by skin test assay, occur in sensitized mice in response to challenge with a class I-restricted synthetic peptide related to a poorly immunogenic tumor rejection Ag, P815AB, of murine mastocytoma cells. Efficient priming for this response, which requires functional CD4+ cells and production of IFN-gamma in the host, is achieved by transfer of dendritic cells (DC) pulsed in vitro with a physical mixture of P815AB and T… CONTINUE READING

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