IL-12 induces autophagy in human breast cancer cells through AMPK and the PI3K/Akt pathway.

@article{Lin2017IL12IA,
  title={IL-12 induces autophagy in human breast cancer cells through AMPK and the PI3K/Akt pathway.},
  author={Yan Lin and Wenbin Kuang and Bi-tao Wu and Chang-li Xie and Cui-ying Liu and Zhiguang Tu},
  journal={Molecular medicine reports},
  year={2017},
  volume={16 4},
  pages={
          4113-4118
        }
}
Interleukin-12 (IL-12) serves an important role in immune responses and antitumor activity. The study of the association between autophagy and cancer cells remains controversial. The present study aimed to investigate the effect of IL‑12 on autophagy in the human breast cancer cell lines MDA‑MB‑231 and MCF‑7, and the possible molecular mechanism. Breast cancer cells were treated with different concentrations of recombinant IL‑12. The expression of the autophagy-associated protein microtubule… 

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References

SHOWING 1-10 OF 32 REFERENCES

Induction of autophagy and inhibition of tumorigenesis by beclin 1

TLDR
It is shown that beclin 1 is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at decreased levels in human breast carcinoma, suggesting that decreased expression of Autophagy proteins may contribute to the development or progression of breast and other human malignancies.

Autophagy Enhances the Aggressiveness of Human Colorectal Cancer Cells and Their Ability to Adapt to Apoptotic Stimulus

TLDR
Investigation of LC3B-II and active caspase-3 expression in human colorectal cancer to elucidate the role of autophagy and explore the relationship of autophileagy with apoptosis found it to have a prosurvival role.

IL-12 could induce monocytic tumor cells directional differentiation

TLDR
It is revealed that IL-12 could induce monocytic tumor cells directional differentiation into macrophage-like cells, and its mechanism is possible connected with the up-regulation of c-fms expression and the phosphorylation of CSF-1R Tyr-809 site.

AMPK and cell proliferation – AMPK as a therapeutic target for atherosclerosis and cancer

TLDR
Observations suggest that AMPK activation is a logical therapeutic target for diseases rooted in cellular proliferation, including atherosclerosis and cancer.

Different involvement of autophagy in human malignant glioma cell lines undergoing irradiation and temozolomide combined treatments

TLDR
Results might enforce the concept that autophagy‐associated cell death might constitute a possible adjuvant therapeutic strategy to enhance the conventional GB treatment.

Down-regulation of AKT combined with radiation-induced autophagy and apoptosis roles in MCF-7 cells.

TLDR
It is concluded that autophagy and apoptosis can be induced by radiation and inhibition of autophophagy can increase apoptosis, and Akt is a molecule that down-regulates autophagic and apoptotic activity; blocking Akt can enhance autophagous activity and become a new focus in breast cancer radiotherapy.

Autophagy as a therapeutic target in cancer

TLDR
Current knowledge on the regulation and dual function of autophagy in tumorigenesis, as well as ongoing efforts in modulating autophagic for cancer treatment and prevention are summarized.

AMPK, the metabolic syndrome and cancer.

PI3K/Akt signaling in osteosarcoma.

Portrait of the PI3K/AKT pathway in colorectal cancer.