IL-12 induces IFN-gamma expression and secretion in mouse peritoneal macrophages.

  title={IL-12 induces IFN-gamma expression and secretion in mouse peritoneal macrophages.},
  author={Patrizia Puddu and Laura Fantuzzi and Paola Borghi and Barbara Varano and Giuseppe Rainaldi and Eric Guillemard and Walter Malorni and Pascale Roland Nicaise and Stanley F. Wolf and Filippo Belardelli and Sandra Gessani},
  journal={Journal of immunology},
  volume={159 7},
We previously reported that resting mouse peritoneal macrophages (PM) constitutively express low levels of IFN-gamma, whose production is consistently enhanced by exogenous IFN-gamma. In this study, we investigated the effects of IL-12 on the replication of vesicular stomatitis virus and on IFN-gamma gene expression in mouse PM. The addition of IL-12 to freshly explanted PM resulted in the persistence of an antiviral state to vesicular stomatitis virus, while control PM progressively became… CONTINUE READING


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