IL-12 enhances the antitumor actions of trastuzumab via NK cell IFN-γ production.

  title={IL-12 enhances the antitumor actions of trastuzumab via NK cell IFN-γ production.},
  author={Alena Cristina Jaime-Ramirez and Bethany L. Mundy-Bosse and SriVidya Kondadasula and Natalie B. Jones and Julie M. Roda and Aruna Mani and Robin Parihar and Volodymyr I. Karpa and Tracey L. Papenfuss and Krista M. LaPerle and Elizabeth Biller and Amy G Lehman and Abhik Ray Chaudhury and David Jarjoura and Richard W. Burry and William E Carson},
  journal={Journal of immunology},
  volume={186 6},
The antitumor effects of therapeutic mAbs may depend on immune effector cells that express FcRs for IgG. IL-12 is a cytokine that stimulates IFN-γ production from NK cells and T cells. We hypothesized that coadministration of IL-12 with a murine anti-HER2/neu mAb (4D5) would enhance the FcR-dependent immune mechanisms that contribute to its antitumor activity. Thrice-weekly therapy with IL-12 (1 μg) and 4D5 (1 mg/kg) significantly suppressed the growth of a murine colon adenocarcinoma that was… CONTINUE READING
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