IL-12 eliminates the Th-2 dependent protective immune response of mice to larval Strongyloides stercoralis.

@article{Rotman1997IL12ET,
  title={IL-12 eliminates the Th-2 dependent protective immune response of mice to larval Strongyloides stercoralis.},
  author={Harris L. Rotman and Silvia Schnyder-Candrian and Phillip A. Scott and Thomas J. Nolan and Gerhard A. Schad and David Abraham},
  journal={Parasite immunology},
  year={1997},
  volume={19 1},
  pages={29-39}
}
The goal of the present study was to determine if immune-mediated killing of S. stercoralis L3 in mice could be modulated by shifting from a Th-2 to a Th-1 type immune response. L3 killing in immunized mice was ablated in CD4+ T cell-depleted animals, but not in CD8+ T cell-depleted or beta 2-microglobulin-deficient mice. Treatment of immunized mice with IL-4 or IL-5 neutralizing MoAb significantly reduced the protective effects of vaccination against S. stercoralis, while protective immunity… CONTINUE READING