IL-12 drives functional plasticity of human group 2 innate lymphoid cells

@inproceedings{Lim2016IL12DF,
  title={IL-12 drives functional plasticity of human group 2 innate lymphoid cells},
  author={Ai Ing Lim and Silvia Menegatti and Jacinta Bustamante and Lionel le Bourhis and Matthieu Allez and Lars Rogge and J. Hugo P{\'e}rez Casanova and Hans Yssel and James P Di Santo},
  booktitle={The Journal of experimental medicine},
  year={2016}
}
Group 2 innate lymphoid cells (ILC2) include IL-5- and IL-13-producing CRTh2(+)CD127(+)cells that are implicated in early protective immunity at mucosal surfaces. Whereas functional plasticity has been demonstrated for both human and mouse ILC3 subsets that can reversibly give rise to IFN-γ-producing ILC1, plasticity of human or mouse ILC2 has not been shown. Here, we analyze the phenotypic and functional heterogeneity of human peripheral blood ILC2. Although subsets of human CRTh2(+)ILC2… CONTINUE READING
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