IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and men.

@article{Jouanguy1999IL12AI,
  title={IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and men.},
  author={Emmanuelle Jouanguy and Rainer D{\"o}ffinger and St{\'e}phanie Dupuis and Anna{\"i}ck Pallier and Fr{\'e}d{\'e}ric Altare and Jean Casanova},
  journal={Current opinion in immunology},
  year={1999},
  volume={11 3},
  pages={346-51}
}
The development of gene-knockout mice and the identification of gene-deficient humans have improved our understanding of the role of IL-12 and IFN-gamma in host defense. Comparison of experimental and natural infections has shown that animals and humans genetically deficient in immunity mediated by IL-12 or IFN-gamma are highly susceptible to mycobacteria and salmonella. Impaired secretion of, or response to, IFN-gamma is the common pathogenic mechanism that accounts for impaired granuloma… CONTINUE READING