IL-12 and IFN-gamma are required for initiating the protective Th1 response to pulmonary cryptococcosis in resistant C.B-17 mice.

@article{Hoag1997IL12AI,
  title={IL-12 and IFN-gamma are required for initiating the protective Th1 response to pulmonary cryptococcosis in resistant C.B-17 mice.},
  author={Kathleen A. Hoag and Mary Lipscomb and Angelo A Izzo and Nancy E. Street},
  journal={American journal of respiratory cell and molecular biology},
  year={1997},
  volume={17 6},
  pages={733-9}
}
A murine model was used to assess the role of cytokines in initiating protective T-cell-mediated immunity in the lung. A pulmonary infection was initiated by intratracheal inoculation of Cryptococcus neoformans (Cne). Previously, we had established that Cne lung clearance was mouse-strain-specific: C.B-17 mice were resistant and developed a Th1-like response, whereas C57BL/6 mice were susceptible and did not develop a Th1 response. In the present study we showed that monoclonal anti-interferon… CONTINUE READING
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