IL-12 alone and in synergy with IL-18 inhibits osteoclast formation in vitro.

@article{Horwood2001IL12AA,
  title={IL-12 alone and in synergy with IL-18 inhibits osteoclast formation in vitro.},
  author={Nicole J. Horwood and Jan N Elliott and Thomas J Martin and Matthew T. Gillespie},
  journal={Journal of immunology},
  year={2001},
  volume={166 8},
  pages={4915-21}
}
IL-12, like IL-18, was shown to potently inhibit osteoclast formation in cultures of cocultures of murine osteoblast and spleen cells, as well as in adult spleen cells treated with M-CSF and receptor activator of NF-kappaB ligand (RANKL). Neither IL-12 nor IL-18 was able to inhibit RANKL-induced osteoclast formation in cultured RAW264.7 cells, demonstrating that IL-12, like IL-18, was unable to act directly on osteoclastic precursors. IL-12, like IL-18, was found to act by T cells, since… CONTINUE READING

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