IL-12-Independent costimulation pathways for interferon-gamma production in familial disseminated Mycobacterium avium complex infection.

@article{Frucht1999IL12IndependentCP,
  title={IL-12-Independent costimulation pathways for interferon-gamma production in familial disseminated Mycobacterium avium complex infection.},
  author={David M. Frucht and David I. Sandberg and Margaret R. Brown and S M Gerstberger and Steven M Holland},
  journal={Clinical immunology},
  year={1999},
  volume={91 2},
  pages={234-41}
}
We have described previously a family with an apparent genetic susceptibility to disseminated Mycobacterium avium complex infection and an underlying defect in IL-12 regulation leading to abnormally low interferon-gamma production. Their T cells appear to act normally when in the presence of normal accessory cells. Cell-to-cell contact was necessary for normal monocytes to complement the familial patient monocyte defect, suggesting the familial defect in interferon-gamma costimulation involves… CONTINUE READING

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