IL-12 Deficiency in MRL-Fas Mice Delays Nephritis and Intrarenal IFN- Expression, and Diminishes Systemic Pathology


Autoimmune disease in MRL-Fas lpr mice is characterized by fatal nephritis, systemic pathology, and autoantibodies, mimicking human lupus. We previously reported that 1) intrarenal IL-12 elicits nephritis by fostering the accumulation of intrarenal IFN-␥-secreting T cells, and 2) MRL-Fas lpr mice deficient in the IFN-␥ receptor were spared from nephritis… (More)


9 Figures and Tables

Slides referencing similar topics