IL-12 Deficiency in MRL-Fas Mice Delays Nephritis and Intrarenal IFN- Expression, and Diminishes Systemic Pathology

Abstract

Autoimmune disease in MRL-Fas lpr mice is characterized by fatal nephritis, systemic pathology, and autoantibodies, mimicking human lupus. We previously reported that 1) intrarenal IL-12 elicits nephritis by fostering the accumulation of intrarenal IFN-␥-secreting T cells, and 2) MRL-Fas lpr mice deficient in the IFN-␥ receptor were spared from nephritis… (More)

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