• Published 2008


  author={高蕾 and 鲍朗 and 郝牧 and 章乐 and 秦紫芳},
Objective To investigate the immunogenicity of vaccine strategies about human interleukin 12 associated with combined DNA (Ag85A and ESAT-6) prime-BCG boost. Methods BALB/c mice were divided into PBS negative control and 4 immunity groups: BCG group, DNA/BCG group, DNA+IL-12/BCG group and DNA/BCG+IL-12 group. All mice received three immunizations at 2-week interval. Specific IgG antibody in serum of mice was determined with indirect ELISA in 4, 6, 8 weeks respectively after final vaccination… CONTINUE READING