IL-12, IFN-gamma, and T cell proliferation to measles in immunized infants.

@article{Gans1999IL12IA,
  title={IL-12, IFN-gamma, and T cell proliferation to measles in immunized infants.},
  author={Hayley A. Gans and Yvonne Maldonado and Linda L. Yasukawa and Judith Beeler and Susette A. Audet and Mary M. Rinki and Ross Dehovitz and Ann Margaret Arvin},
  journal={Journal of immunology},
  year={1999},
  volume={162 9},
  pages={5569-75}
}
Measles infection in infants is associated with severe complications, and secondary infections are attributed to generalized immunosuppression. Measles binding to its monocyte receptor down-regulates IL-12 which is expected to diminish Th1-like cytokine responses, including IFN-gamma. Whether young infants can be immunized effectively against measles is an important public health issue. We evaluated Ag-specific IL-12, IFN-gamma, and T cell responses of infants at 6 (n = 60), 9 (n = 46), or 12… CONTINUE READING

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