IL-11 activates human endothelial cells to resist immune-mediated injury.

@article{Mahboubi2000IL11AH,
  title={IL-11 activates human endothelial cells to resist immune-mediated injury.},
  author={Keyvan Mahboubi and Barbara C. Biedermann and Joseph M. Carroll and Jordan S Pober},
  journal={Journal of immunology},
  year={2000},
  volume={164 7},
  pages={3837-46}
}
IL-11, a gp130-signaling cytokine, is protective in several in vivo models of immune-mediated and inflammatory injury. HUVECs express IL-11 receptor alpha-chain and gp130. Human IL-11 causes rapid (2-10 min) tyrosine phosphorylation of gp130. IL-11 at 0.1 and 10 ng/ml induces tyrosine phosphorylation of STAT3 and STAT1, respectively, although maximal responses require 50 ng/ml. Phospho-STAT3 and phospho-STAT1 levels peak rapidly (2.5 min) and disappear by 60 min. The p42 and p44 mitogen… CONTINUE READING
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