IL-10 within the CNS is necessary for CD4+ T cells to mediate neuroprotection.

@article{Xin2011IL10WT,
  title={IL-10 within the CNS is necessary for CD4+ T cells to mediate neuroprotection.},
  author={Junping Xin and Derek A. Wainwright and Nichole A Mesnard and Craig J Serpe and Virginia M. Sanders and Kathryn J Jones},
  journal={Brain, behavior, and immunity},
  year={2011},
  volume={25 5},
  pages={820-9}
}
We have previously shown that immunodeficient mice exhibit significant facial motoneuron (FMN) loss compared to wild-type (WT) mice after a facial nerve axotomy. Interleukin-10 (IL-10) is known as a regulatory cytokine that plays an important role in maintaining the anti-inflammatory environment within the central nervous system (CNS). IL-10 is produced by a number of different cells, including Th2 cells, and may exert an anti-apoptotic action on neurons directly. In the present study, the role… CONTINUE READING