IL-10 supplementation increases Tregs and decreases hypertension in the RUPP rat model of preeclampsia.

@article{Harmon2015IL10SI,
  title={IL-10 supplementation increases Tregs and decreases hypertension in the RUPP rat model of preeclampsia.},
  author={Ashlyn Christine Harmon and Denise C Cornelius and Lorena Machado Amaral and Adrienne Paige and Florian Herse and Tarek Mostafa Ibrahim and Gert Wallukat and Jessica L. Faulkner and Janae Moseley and Ralf Dechend and Babbette LaMarca},
  journal={Hypertension in pregnancy},
  year={2015},
  volume={34 3},
  pages={
          291-306
        }
}
OBJECTIVE The reduced uterine perfusion pressure (RUPP) rat model of preeclampsia was used to determine the effects of added interleukin-10 (IL-10) on Tregs and hypertension in response to placental ischemia and how the decrease in these anti-inflammatory factors mediates the pathophysiology of preeclampsia. METHODS IL-10 (2.5 ng/kg/d) was infused via osmotic mini-pump implanted intraperitoneally on day 14 of gestation and, at the same time, the RUPP procedure was performed. RESULTS IL-10… CONTINUE READING
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in response to placental ischemia during pregnancy

  • A Boonstra, R Rajsbaum, M Holman
  • 2013

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