IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis.

@article{Kobayashi2012IL10RI,
  title={IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis.},
  author={Taku Kobayashi and Katsuyoshi Matsuoka and Shehzad Zafar Sheikh and Steven M. Russo and Yoshiyuki Mishima and Colm B. Collins and Edwin Dezoeten and Christopher L. Karp and Jenny Pan-Yun Ting and Ryan Balfour Sartor and Scott Eric Plevy},
  journal={Journal of immunology},
  year={2012},
  volume={189 4},
  pages={1792-9}
}
To prevent excessive inflammatory responses to commensal microbes, intestinal macrophages, unlike their systemic counterparts, do not produce inflammatory cytokines in response to enteric bacteria. Consequently, loss of macrophage tolerance to the enteric microbiota plays a central role in the pathogenesis of inflammatory bowel diseases. Therefore, we examined whether the hyporesponsive phenotype of intestinal macrophages is programmed by prior exposure to the microbiota. IL-10, but not in vivo… CONTINUE READING