IL-10 production in B cells is confined to CD154+ cells in patients with systemic lupus erythematosus.

@article{DazAlderete2004IL10PI,
  title={IL-10 production in B cells is confined to CD154+ cells in patients with systemic lupus erythematosus.},
  author={Andrea D{\'i}az-Alderete and Jos{\'e} Carlos Crisp{\'i}n and Mar{\'i}a In{\'e}s Vargas-Rojas and Jorge Alcocer-Varela},
  journal={Journal of autoimmunity},
  year={2004},
  volume={23 4},
  pages={379-83}
}
The immunological hallmark of SLE is B cell hyperactivity. CD154 (CD40-L) is normally expressed in activated T cells, and plays an important role in T-B interactions. Its expression is increased in SLE T cells. Additionally, its expression on B cells leads to the development of SLE-like disease in a transgenic model. IL-10 is a key cytokine in the disturbed SLE immune system. The aim of this work was to explore the relation between IL-10 and CD154 expression in SLE B cells. We studied 11 SLE… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

B Cells with Regulatory Function in Human Diseases

Autoimmune diseases and therapeutic approaches : open access • 2014
View 3 Excerpts
Highly Influenced

Regulatory B cells in skin and connective tissue diseases.

Journal of dermatological science • 2010
View 2 Excerpts

Similar Papers

Loading similar papers…