IL-10 mediates suppression of the CD8 T cell IFN-gamma response to a novel viral epitope in a primed host.

@article{Liu2003IL10MS,
  title={IL-10 mediates suppression of the CD8 T cell IFN-gamma response to a novel viral epitope in a primed host.},
  author={Xiao Song Liu and Yan Xu and Lani Hardy and Vithagna Khammanivong and Weiming Zhao and Germain J. P. Fernando and Graham R Leggatt and Ian H Frazer},
  journal={Journal of immunology},
  year={2003},
  volume={171 9},
  pages={4765-72}
}
Priming to Ag can inhibit subsequent induction of an immune response to a new epitope incorporated into that Ag, a phenomenon referred to as original antigenic sin. In this study, we show that prior immunity to a virus capsid can inhibit subsequent induction of the IFN-gamma effector T cell response to a novel CD8-restricted antigenic epitope associated with the virus capsid. Inhibition does not involve Ab to the virus capsid, as it is observed in animals lacking B cells. CD8-restricted virus… CONTINUE READING

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