IL-10 is required for human CD4(+)CD25(+) regulatory T cell-mediated suppression of xenogeneic proliferation.

Cellular rejection of xenografts is predominantly mediated by CD4(+) T cells. Human CD4(+)CD25(+) regulatory T cells (Tregs) are capable of suppressing the CD4(+) T cell-mediated xenogeneic response in vitro. However, the precise mechanisms that are involved remain to be identified. In this study, we analyzed whether interleukin-10 (IL-10) is required for… CONTINUE READING